From their work in the tiny roundworm, Caenorhabditis elegans, the scientists discovered a change in an evolutionarily conserved gene called PUF60, which made the worms long lived but at the same time dampened the immune response. Worms with this change lived about 20% longer than normal worms, but when they were infected with certain bacteria, they succumbed more quickly to the infection. This means that an overactive immune system also has a price: it shortens life span. Conversely, a less active immune system pays off as longer life span — as long as the animal does not die from an infection.
How does PUF60 regulate this fine balance between a maintained immune system and longevity? PUF60 works as a so-called “splicing factor,” and is involved in the removal (or “splicing out”) of segments in the ribonucleic acid, RNA. This process is essential to generate functional proteins.
The scientists found that the genetically changed PUF60 perturbs this process and alters the regulation of other genes that are involved in immune functions. “We’re excited by this finding because it implicates a very fundamental process in the cell to immunity,” says Adam Antebi. “These observations of course raise further questions. Notably pinpointing how PUF60 activity affects immunity and longevity, and how these two processes are balanced will be central to understanding the relationship between inflammation and ageing.”
Source: Max-Planck-Gesellschaft
Like!! Really appreciate you sharing this blog post.Really thank you! Keep writing.
Thank you ever so for you article post.
A big thank you for your article.
I used to be able to find good info from your blog posts.
bupropion sr
467101 781265We will supply deal reviews, deal coaching, and follow up to ensure you win the deals you cant afford to lose. 211618
427725 923897Woh I like your weblog posts, saved to fav! . 575286
725019 78614Having read this I thought it was extremely informative. I appreciate you taking the time and effort to put this post together. I once once more find myself spending approach to much time both reading and commenting. But so what, it was nonetheless worth it! 602127
181765 998059of course like your web-site nevertheless you need to check the spelling on quite some of your posts. Several them are rife with spelling issues and I to discover it quite bothersome to inform the reality nevertheless Ill surely come back once more. 923715
785033 201125The vacation delivers on offer are : believed a selection of some of the most selected and in addition budget-friendly global. Any of these lodgings tend to be quite used along units may possibly accented by indicates of pretty shoreline supplying crystal-clear turbulent waters, concurrent with the Ocean. hotels packages 33742
360069 703236Some genuinely nice and utilitarian info on this web website , likewise I believe the style and design contains superb capabilities. 526420
124089 71492You created some decent points there. I looked on the internet for the problem and discovered most individuals will go coupled with along together with your site. 318342
592450 863108Perfectly composed content , thankyou for entropy. 208477
209849 151116Hoping to go into business venture world-wide-web Indicates revealing your products or services furthermore companies not only to ladies locally, but nevertheless , to many prospective clients in which are online in most cases. e-wallet 951386
879266 771840I admire the beneficial facts you offer inside your articles. I will bookmark your weblog and also have my children verify up here often. Im extremely confident theyll learn plenty of new points proper here than anybody else! 387267
25808 730103very nice post, i undoubtedly adore this outstanding site, carry on it 990460
30178 373445Rattling clean web internet site , appreciate it for this post. 21416
308182 904085Maintain all the articles coming. I love reading by means of your points. Cheers. 121581
146220 701259I as effectively believe thence , perfectly pent post! . 37909
448727 572716I conceive this web site has got some really exceptional info for everyone : D. 788868
530078 575383Youre so cool! I dont suppose Ive learn anything like this before. So good to discover any person with some authentic thoughts on this topic. realy thank you for starting this up. this web site is something that is wanted on the internet, someone with just a little bit originality. helpful job for bringing something new towards the internet! 120172
425984 955945Some truly nice stuff on this internet website , I like it. 101747
978066 235986I want to start a blog but would like to own the domain. Any concepts how to go about this?. 793795
830665 81949Yay google is my world beater aided me to find this outstanding site! . 358226
642149 100279I actually like this blog internet site, will undoubtedly come back once again. Make certain you carry on creating quality content material articles. 629332
406746 965286I actually like your writing style, great information, appreciate it for posting : D. 939953
36999 942835Hey. Extremely nice internet website!! Man .. Outstanding .. Amazing .. Ill bookmark this internet web site and take the feeds alsoI am happy to locate so a lot beneficial info here within the write-up. Thanks for sharing 916916
294259 707531Nicely written articles like yours renews my faith in todays writers. Youve written details I can lastly agree on and use. Thank you for sharing. 174897
191538 579962An intriguing discussion is going to be worth comment. I believe that you can write read much more about this topic, could nicely certainly be a taboo topic but usually folks are inadequate to chat on such topics. To a higher. Cheers 560334