Now, an international team of researchers led by neuroscientists at Harvard Medical School has identified the olfactory cell types most vulnerable to infection by SARS-CoV-2, the virus that causes COVID-19.Surprisingly, sensory neurons that detect and transmit the sense of smell to the brain are not among the vulnerable cell types.
Reporting in Science Advances on July 24, the research team found that olfactory sensory neurons do not express the gene that encodes the ACE2 receptor protein, which SARS-CoV-2 uses to enter human cells. Instead, ACE2 is expressed in cells that provide metabolic and structural support to olfactory sensory neurons, as well as certain populations of stem cells and blood vessel cells.
The findings suggest that infection of nonneuronal cell types may be responsible for anosmia in COVID-19 patients and help inform efforts to better understand the progression of the disease.
“Our findings indicate that the novel coronavirus changes the sense of smell in patients not by directly infecting neurons but by affecting the function of supporting cells,” said senior study author Sandeep Robert Datta, associate professor of neurobiology in the Blavatnik Institute at HMS.
This implies that in most cases, SARS-CoV-2 infection is unlikely to permanently damage olfactory neural circuits and lead to persistent anosmia, Datta added, a condition that is associated with a variety of mental and social health issues, particularly depression and anxiety.
“I think it’s good news, because once the infection clears, olfactory neurons don’t appear to need to be replaced or rebuilt from scratch,” he said. “But we need more data and a better understanding of the underlying mechanisms to confirm this conclusion.”
Source: Harvard Medical School
492306 137996Youre so cool! I dont suppose Ive read anything like this before. So nice to find somebody with some original thoughts on this subject. realy thank you for starting this up. this web site is something that is needed on the internet, someone with a little originality. beneficial job for bringing something new to the internet! 944905
496537 114940As a result youll need ultra powerful online enterprise ideas to keep operating in finding into matters proper your incredible web-based function. MLM 721870
206201 252053I want to start a blog but would like to own the domain. Any concepts how to go about this?. 765878
250997 653890Cool text dude, maintain up the good function, just shared this with the mates 313968
751673 707223You created some initial rate factors there. I regarded on the web for the difficulty and located a lot of people will associate with with your web site. 989120
373240 14740This web site is often a walk-through for all of the understanding you wanted concerning this and didnt know who should. Glimpse here, and youll totally discover it. 812730
778805 988589How can I attract much more hits to my composing weblog? 874544
28301 789919Superb blog here! Also your website loads up quick! What host are you employing? Can I get your affiliate link to your host? I wish my site loaded up as swiftly as yours lol 591628
83537 956753Quite interesting subject , thanks for putting up. 62435
52472 456865Hey! Do you know if they make any plugins to help with SEO? Im trying to get my blog to rank for some targeted keywords but Im not seeing very excellent outcomes. In the event you know of any please share. Thanks! 276066
494269 368592Hello there! Good post! Please inform us when all could see a follow up! 971910
41552 266736Hello! I could have sworn Ive been to this blog before but following browsing via some with the post I realized its new to me. Anyways, Im certainly happy I found it and Ill be book-marking and checking back regularly! 78402
645898 342455Hey! I merely wish to give an enormous thumbs up for the very good data youve got here on this post. I will likely be coming back to your weblog for much more soon. 344898
436162 537103extremely nice put up, i undoubtedly enjoy this internet web site, carry on it 133426
572548 756360I like the valuable information you give within your articles. Ill bookmark your blog and check once more here regularly. Im quite certain Ill learn numerous new stuff appropriate here! Very good luck for the next! 552798
946503 676181Youve made various nice points there. I did specific search terms about the matter and found mainly individuals will believe your internet site 344613
678655 621109Attractive part of content material. I just stumbled upon your web site and in accession capital to claim that I acquire in fact enjoyed account your blog posts. Any way Ill be subscribing to your feeds and even I achievement you get entry to constantly speedily. 572653
560160 20063Keep up the good work! 661727
46137 836545Discovered your weblog and decided to have a study on it, not what I normally do, but this blog is fantastic. Awesome to see a website thats not spammed, and really makes some sense. Anyway, wonderful write up. 557464
296308 95895Wonderful post, Im looking forward to hear much more from you!! 910734
great article
658590 786883Im often to blogging and i in actual fact respect your content. The piece has actually peaks my interest. Im going to bookmark your content material and preserve checking for brand new data. 332719
918636 938892Woh I like your articles , saved to fav! . 758581
435796 971464Enjoyed examining this, quite excellent stuff, thanks . 9152
466342 42419i just didnt require a kindle at 1st, but when receiving one for christmas im utterly converted. It supply genuine advantages over a book, and makes it such a lot additional convenient. i might undoubtedly advocate this item: 468469
72209 345672Hello my family member! I wish to say that this post is incredible, wonderful written and come with approximately all vital infos. I would like to see extra posts like this . 419953
162917 321015Cheapest player speeches and toasts, or maybe toasts. continue to be brought about real estate . during evening reception tend to be likely to just be comic, witty and therefore instructive as well. finest man speeches totally free 207404
592915 979263 Nice post. I learn something much more challenging on different blogs everyday. It will always be stimulating to read content from other writers and practice just a little something from their store. Id prefer to use some with the content material on my blog whether you dont mind. Natually Ill give you a link on your internet blog. Thanks for sharing. 586772
918603 527773You produced some decent points there. I looked online for your issue and located most people will go together with with the internet site. 906796
695844 866389Outstanding blog here! Also your internet website loads up fast! What host are you using? Can I get your affiliate link to your host? I wish my site loaded up as swiftly as yours lol 767902